The severity of the disease is strongly correlated to the age of onset. Symptoms generally appear in young children (usually between 2-6 years old) who previously had fairly normal development. With proactive, comprehensive medical care the symptoms of VWM can be well-managed to give the individual the best quality of life possible. VWM is chronic and progressive, and is unusual in that periods of rapid and severe deterioration can be caused by minor head trauma, fevers and even anesthesia.Īlthough there is currently no cure for VWM, it is treatable. O Vanishing White Matter Leukodystrophy with Ovarian Failure How does VWM affect the individual? O Vanishing White Matter Leukodystrophy (VWM) O Childhood Ataxia with diffuse CNS Hypomyelination (CACH) In doing so, it permanently affects transmission of brain signals to the rest of the body. VWM, also known as Childhood Ataxia with Central Nervous System Hypomyelination (CACH), is an extremely rare neurological condition that destroys myelin, the brain’s white matter, or myelin. Vanishing White Matter Disease (VWM) is one of more than 50 conditions that affect the white matter, or myelin, of the brain known collectively as Leukodystrophies. What is Vanishing White Matter Disease (VWM)?
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